Patents

1. Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics

EP Publication No. EP2147115

Publication Date: 2010-01-27

Authors: John T. McDevitt, Nicolaos Christodoulides, Jeff Ebersole, Craig S. Miller & Pierre Floriano

2. Method and system for the analysis of saliva using a sensor array

US Publication No. US7651868

Publication Date: 2010-01-26

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Nick J. Christodoulides

A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle.; Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

3. A microchip-based system for HIV diagnostics

DE Publication No. DE602004024285

Publication Date: 2010-01-07

Authors: Bruce Walker, William Rodriguez, John T. McDevitt & Nick J. Christodoulides

4. A microchip-based system for HIV diagnostics

AT Publication No. AT449962

Publication Date: 2009-12-15

Authors: Bruce Walker, William Rodriguez, John T. McDevitt & Nick J. Christodoulides

5. A microchip-based system for HIV diagnostics

EP Publication No. EP1590669

Publication Date: 2009-11-25

Authors: Bruce Walker, William Rodriguez, John T. McDevitt & Nick J. Christodoulides

The invention relates to microchip-based assays to measure HIV-associated analytes of interest (e.g., CD4 lymphocytes, HIV RNA and liver enzymes) in a sample from a subject infected with the HIV virus. Methods of the present invention are optimal for use in monitoring HIV disease in resource-poor settings.

6. Capture and detection of microbes by membrane methods

EP Publication No. EP2107120

Publication Date: 2009-10-07

Authors: John T. McDevitt, Pierre Floriano & Nick J. Christodoulides

7. Methods and compositions related to determination and use of white blood cell counts

US Publication No. US2009215072

Publication Date: 2009-08-27

Authors: John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas & Patrick E. Rogers

8. System and method of analyte detection using differential receptors

US Publication No. US2009215646

Publication Date: 2009-08-27

Authors: Eric V. Anslyn, John T. McDevitt, Jason B. Shear, Dean P. Neikirk, Aaron T. Wright & Zhenlin Zhong

9. Systems and methods including self-contained cartridges with detection systems and fluid delivery systems

ZA Publication No. ZA200800413

Publication Date: 2009-07-29

Authors: John T. McDevitt, Nicolaos J. Christodoulides, Glennon W. Simmons Karri Ballard & Pierre N. Floriano

10. Method and system for the detection of cardiac risk factors

AU Publication No. AU2009202457

Publication Date: 2009-07-16

Authors: Dean P. Neikirk, Eric V. Anslyn, Nicolaos Christodoulides, Jason B. Shear & John T. McDevitt

A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle.; Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

11. Method and system for the detection of cardiac risk factors

AU Publication No. AU2003228711

Publication Date: 2009-07-16

Authors: Jason B. Shear, Nick J. Christodoulides, John T. McDevitt, Eric V. Anslyn & Dean P. Neikirk

12. Fluid based analysis of multiple analytes by a sensor array

IN Publication No. IN231681

Publication Date: 2009-03-07

Authors: John T. McDevitt, Pierre Floriano & Nick J. Christodoulides

Methods and systems for detecting the presence of analytes using a membrane based detection system are described. A fluid sample is passed through a membrane based detection system (100). Particulate analytes (e.g., microbes) are captured by the membrane (110). Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.

13. Detecting multiple types of leukocytes

EP Publication No. EP2027249

Publication Date: 2009-02-25

Authors: Pierre N. Floriano, Nicolaos Christodoulides, Karri Ballard & John T. McDevitt

14. Fluid based analysis of multiple analytes by a sensor array

US Publication No. US7491552

Publication Date: 2009-02-17

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

15. Detecting tumor biomarker in oral cancer

EP Publication No. EP2021491

Publication Date: 2009-02-11

Authors: Shannon Weigum, Pierre N. Floriano, Nicolaos Christodoulides & John T. McDevitt

16. Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics

US Publication No. US2008300798

Publication Date: 2008-12-04

Authors: John T. McDevitt, Nicolaos Christodoulides, Pierre Floriano, Craig S. Miller & Jeff Ebersole

17. Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics

WO Publication No. WO2008131039

Publication Date: 2008-10-30

Authors: John T. McDevitt, Nicolaos Christodoulides, Jeff Ebersole, Craig S. Miller & Pierre Floriano

Embodiments of the invention include methods by which cardiac biomarkers are assigned an index (cardiovascular biomarker index-cardiobioindex, CBI) as a means to describe the utility of each biomarker, or combination of biomarkers for risk evaluation, diagnosis or prognosis of cardiovascular disease status.

18. Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics

CA Publication No. CA2697357

Publication Date: 2008-10-30

Authors: John T. McDevitt, Nicolaos Christodoulides, Jeff Ebersole, Craig S. Miller & Pierre Floriano

19. Portable sensor array system

US Publication No. US2008219891

Publication Date: 2008-09-11

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

20. Detecting human or animal immunoglobin-E

AT Publication No. AT403145

Publication Date: 2008-08-15

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

21. Portable sensor array system

EP Publication No. EP1255980

Publication Date: 2008-06-30

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

22. Methods and compositions related to determination and use of white blood cell counts

EP Publication No. EP1910824

Publication Date: 2008-04-16

Authors: John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas & Patrick E. Rogers

23. Systems and methods including self-contained cartridges with detection systems and fluid delivery systems

EP Publication No. EP1899450

Publication Date: 2008-03-19

Authors: John T. McDevitt, Karri Ballard, Nicolaos J. Christodoulides & Pierre N. Floriano, Glennon W. Simmons

24. Detecting multiple types of leukocytes

US Publication No. US2008050830

Publication Date: 2008-02-28

Authors: Pierre N. Floriano, Nicolaos Christodoulides, Karri Ballard & John T. McDevitt

25. Detecting tumor biomarker in oral cancer

US Publication No. US2008038738

Publication Date: 2008-02-14

Authors: Shannon Weigum, Pierre N. Floriano, Nicolaos Christodoulides & John T. McDevitt

26. Portable sensor array system

US Publication No. US7316899

Publication Date: 2008-01-08

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

27. Detecting multiple types of leukocytes

WO Publication No. WO2007134191

Publication Date: 2007-11-22

Authors: Pierre N. Floriano, Nicolaos Christodoulides, Karri Ballard & John T. McDevitt

Methods, systems, and apparatus for detecting multiple types of leukocytes in a blood sample material. A fluid or gas sample may pass through a sieve-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the relative distribution of multiple types of white blood cells in the sample.

28. Detecting multiple types of leukocytes

CA Publication No. CA2651872

Publication Date: 2007-11-22

Authors: Nicolaos Christodoulides, Karri Ballard, Pierre N. Floriano & John T. McDevitt

29. Detecting tumor biomarker in oral cancer

WO Publication No. WO2007134189

Publication Date: 2007-11-22

Authors: Shannon Weigum, Pierre N. Floriano, Nicolaos Christodoulides & John T. McDevitt

Methods and device for detecting the presence of tumor biomarkers in oral squamous cell carcinoma. A membrane based cell capture device allows deliver of cell samples and reagents to the membrane.

30. A method and apparatus for the delivery of samples to a chemical sensor array

DE Publication No. DE60031988

Publication Date: 2007-06-14

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Damon V. Borich

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

31. Methods and compositions related to determination and use of white blood cell counts

WO Publication No. WO2007053186

Publication Date: 2007-05-10

Authors: John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas & Patrick E. Rogers

Described herein are methods and compositions for analyte detection with a portable instrument suitable for point-of-care analyses wherein the device may be used for a differential assay of blood components, such as lymphocyte populations or other cell populations, which can be used in diagnosis, and for monitoring treatment of diseases, such as HIV infection. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular-based analyses in conjunction with microsieve-based analysis cartridges.

32. Methods and compositions related to determination and use of white blood cell counts

AU Publication No. AU2006309284

Publication Date: 2007-05-10

Authors: Pierre N. Floriano, John T. McDevitt, Nicolaos J. Christodoulides, Gary N. Douglas & Patrick E. Rogers

33. Methods and compositions related to determination and use of white blood cell counts

CA Publication No. CA2610793

Publication Date: 2007-05-10

Authors: John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas & Patrick E. Rogers

34. System and method of analyte detection using differential receptors

WO Publication No. WO2007005666

Publication Date: 2007-01-11

Authors: Eric V. Anslyn, John T. McDevitt, Jason B. Shear, Dean P. Neikirk, Aaron T. Wright & Zhenlin Zhong

Methods and systems for detecting the presence of analytes are described. A fluid or gas sample containing one or more analytes may pass through a particle-based sensor array. Detection and analysis techniques may be applied to determine the identity and quantity of the analytes.

35. Systems and methods including self-contained cartridges with detection systems and fluid delivery systems

CA Publication No. CA2613078

Publication Date: 2007-01-04

Authors: Glennon W. Simmons, Pierre N. Floriano, Nicolaos J. Christodoulides, Karri Ballard & John T. McDevitt

Methods, systems, and apparatus for detecting the presence of analytes are described. A fluid or gas sample may pass through a microsieve-based detecti on system and/or a particle- based detection system of a cartridge. Detection a nd analysis techniques may be applied to determine the identity and quantity of the captured analytes.

36. Systems and methods including self-contained cartridges with detection systems and fluid delivery systems

AU Publication No. AU2006261953

Publication Date: 2007-01-04

Authors: Pierre N. Floriano, Karri Ballard, Nicolaos J. Christodoulides, Glennon W. Simmons & John T. McDevitt

37. Systems and methods including self-contained cartridges with detection systems and fluid delivery systems

WO Publication No. WO2007002480

Publication Date: 2007-01-04

Authors: John T. McDevitt, Karri Ballard, Nicolaos J. Christodoulides & Pierre N. Floriano, Glennon W. Simmons

38. System and method for integrating fluids and reagents in self-contained cartridges containing particle and membrane sensor elements

EP Publication No. EP1735618

Publication Date: 2006-12-27

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Nick J. Christodoulides, Karri L. Michael-Ballard, Pierre Floriano & Bruce Bernard

39. Method and apparatus for delivery of samples to a chemical sensor array

AT Publication No. AT346287

Publication Date: 2006-12-15

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Damon V. Borich

40. Method and apparatus for delivery of samples to a chemical sensor array

EP Publication No. EP1204859

Publication Date: 2006-11-22

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Damon V. Borich

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

41. Particle on membrane assay system

EP Publication No. EP1723420

Publication Date: 2006-11-22

Authors: John T. McDevitt, Nick Christodoulides, Pierre Floriano, Karri L. Michael-Ballard & Bruce Bernard

42. Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements

US Publication No. US2006257941

Publication Date: 2006-11-16

Authors: John T. McDevitt, Karri L. Michael-Ballard, Pierre Floriano, Nick J. Christodoulides, Dean P. Neikirk, Eric V. Anslyn & Jason B. Shear

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

43. Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements

US Publication No. US2006257991

Publication Date: 2006-11-16

Authors: John T. McDevitt, Karri L. Michael-Ballard, Pierre Floriano, Nick J. Christodoulides, Dean P. Neikirk, Eric V. Anslyn & Jason B. Shear

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

44. Integration of fluids and reagents into self-contained cartridges containing sensor elements

US Publication No. US2006257993

Publication Date: 2006-11-16

Authors: John T. McDevitt, Karri L. Michael-Ballard, Pierre Floriano, Nick J. Christodoulides, Dean P. Neikirk, Eric V. Anslyn & Jason B. Shear

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

45. Membrane assay system including preloaded particlWO

WO Publication No. WO2006257854

Publication Date: 2006-11-16

Authors: John T. McDevitt, Nick Christodoulides, Pierre Floriano, Karri L. Michael-Ballard & Bruce Bernard

46. System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements and reagent delivery systems

US Publication No. US2006257992

Publication Date: 2006-11-16

Authors: John T. McDevitt, Karri L. Michael-Ballard, Pierre Floriano, Nick J. Christodoulides, Dean P. Neikirk, Eric V. Anslyn & Jason B. Shear

47. A microchip-based system for HIV diagnostics

US Publication No. US2006234209

Publication Date: 2006-10-19

Authors: Bruce D. Walker, William R. Rodriguez, John T. McDevitt

48. Multi-shell microspheres with integrated chromatographic and detection layers for use in array sensors

US Publication No. US2006228256

Publication Date: 2006-10-12

Authors: John T. McDevitt, Adrian Goodey, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

49. Capture and detection of microbes by membrane methods

BRP Publication No. BRP10501090

Publication Date: 2006-10-03

Authors: John T. McDevitt, Pierre Floriano, Nick J. Christodoulides, Adrian Goodey, Dean Neikirk, Eric Anslyn & Jason Shear

Methods and systems for detecting the presence of analytes using a membrane based detection system are described. A fluid sample is passed through a membrane based detection system (100). Particulate analytes (e.g., microbes) are captured by the membrane (110). Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.

50. Method and system for the analysis of saliva using a sensor array

EP Publication No. EP1695082

Publication Date: 2006-08-30

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Nick J. Christodoulides

51. Capture and detection of microbes by membrane methods

ZA Publication No. ZA200500889

Publication Date: 2006-07-26

Authors: John T. McDevitt, Pierre Floriano, Nick J. Christodoulides, Adrian Goodey, Dean Neikirk, Eric Anslyn & Jason Shear

52. A microchip-based system for HIV diagnostics

JP Publication No. JP2006516743

Publication Date: 2006-07-06

Authors: Bruce D. Walker, William R. Rodriguez & John T. McDevitt

53. Multi-shell microspheres with integrated chromatographic and detection layers for use in array sensors

ZA Publication No. ZA200506560

Publication Date: 2006-05-31

Authors: John T. McDevitt, Adrian Goodey, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

54. Capture and detection of microbes by membrane methods

US Publication No. US2006079000

Publication Date: 2006-04-13

Authors: Pierre Floriano, John T. McDevitt & Nick J. Christodoulides

55. Capture and detection of microbes by membrane methods

US Publication No. US2006073585

Publication Date: 2006-04-06

Authors: John T. McDevitt, Pierre Floriano & Nick J. Christodoulides

56. Method and apparatus for the delivery of samples to a chemical sensor array

US Publication No. US7022517

Publication Date: 2006-04-04

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Damon V. Borich

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

57. A microchip-based system for HIV diagnostics

BRP Publication No. BRP10407299

Publication Date: 2006-02-07

Authors: Bruce D. Walker, William R. Rodriguez, John T. McDevitt, Pierre Floriano & Nick J. Christodoulides

58. Capture and detection of microbes by membrane methods

JP Publication No. JP2005533502

Publication Date: 2005-11-10

Authors: John T. McDevitt, Pierre Floriano, Nick J. Christodoulides, Adrian Goodey, Dean Neikirk, Eric Anslyn & Jason Shear

59. Multi-shell microspheres with integrated chromatographic and detection layers for use in array sensors

EP Publication No. EP1590659

Publication Date: 2005-11-02

Authors: John T. McDevitt, Adrian Goodey, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

60. Membrane assay system including preloaded particles

WO Publication No. WO2005090983

Publication Date: 2005-09-29

Authors: John T. McDevitt, Nick Christodoulides, Pierre Floriano, Karri L. Michael-Ballard & Bruce Bernard

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

61. Particle on membrane assay system

WO Publication No. WO2005085854

Publication Date: 2005-09-15

Authors: John T. McDevitt, Nick Christodoulides, Pierre Floriano, Karri L. Michael-Ballard & Bruce Bernard

62. Particle on membrane assay system

CA Publication No. CA2557563

Publication Date: 2005-09-15

Authors: Pierre Floriano, Karri L. Michael-Ballard John T. McDevitt, Nick Christodoulides, & Bruce Bernard

63. System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements

WO Publication No. WO2005085796

Publication Date: 2005-09-15

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Nick J. Christodoulides, Karri L. Michael-Ballard & Pierre Floriano

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

64. System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements and reagent delivery systems

WO Publication No. WO2005085855

Publication Date: 2005-09-15

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Nick J. Christodoulides, Pierre Floriano & Karri L. Michael-Ballard

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

65. System and method for integrating fluids and reagents in self-contained cartridges containing particle and membrane sensor elements

WO Publication No. WO2005083423

Publication Date: 2005-09-09

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Nick J. Christodoulides, Karri L. Michael-Ballard & Pierre Floriano

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

66. System and method for integrating fluids and reagents in self-contained cartridges containing particle and membrane sensor elements

CA Publication No. CA2557549

Publication Date: 2005-09-09

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Nick J. Christodoulides, Karri L. Michael-Ballard, Pierre Floriano & Dean P. Neikirk

67. Particle on membrane assay system

US Publication No. US2005191620

Publication Date: 2005-09-01

Authors: John T. McDevitt, Nick Christodoulides, Pierre Floriano, Karri L. Ballard & Bruce Bernard

Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

68. Method and system for the analysis of saliva using a sensor array

WO Publication No. WO2005059551

Publication Date: 2005-06-30

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Nick J. Christodoulides

A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle.; Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

69. Method and system for the analysis of saliva using a sensor array

CA Publication No. CA2549190

Publication Date: 2005-06-30

Authors: Jason B. Shear, Eric V. Anslyn, John T. McDevitt, Nick J. Christodoulides & Dean P. Neikirk

70. Method and system for the analysis of saliva using a sensor array

AU Publication No. AU2004300168

Publication Date: 2005-06-30

Authors: Nick J. Christodoulides, Jason B. Shear, John T. McDevitt, Dean P. Neikirk & Eric V. Anslyn

71. Capture and detection of microbes by membrane methods

EP Publication No. EP1546367

Publication Date: 2005-06-29

Authors: John T. McDevitt, Pierre Floriano, Nick J. Christodoulides, Adrian Goodey, Dean Neikirk, Eric Anslyn & Jason Shear

72. System and method for the analysis of bodily fluids

US Publication No. US2005136548

Publication Date: 2005-06-23

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

73. Fluid based analysis of multiple analytes by a sensor array

US Publication No. US6908770

Publication Date: 2005-06-21

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

74. Method and system for the detection of cardiac risk

EP Publication No. EP1502097

Publication Date: 2005-02-02

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Nick J. Christodoulides

75. Method and apparatus for the confinement of materials in a micromachined chemical sensor array

JP Publication No. JP2004529323

Publication Date: 2004-09-24

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Byunghwa Park & Yoon Sok Park

76. A microchip-based system for HIV diagnostics

WO Publication No. WO2004072097

Publication Date: 2004-08-26

Authors: Bruce D. Walker, William R. Rodriguez & John T. McDevitt

The invention relates to microchip-based assays to measure HIV-associated analytes of interest (e.g., CD4 lymphocytes, HIV RNA and liver enzymes) in a sample from a subject infected with the HIV virus. Methods of the present invention are optimal for use in monitoring HIV disease in resource-poor settings.

77. A microchip-based system for HIV diagnostics

CA Publication No. CA2515348

Publication Date: 2004-08-26

Authors: John T. McDevitt, Bruce D. Walker, William R. Rodriguez, Nick J. Christodoulides & Pierre Floriano

78. A microchip-based system for HIV diagnostics

AU Publication No. AU2004212464

Publication Date: 2004-08-26

Authors: Bruce D. Walker, William R. Rodriguez & John T. McDevitt

79. Multi-shell microspheres with integrated chromatographic and detection layers for use in array sensors

WO Publication No. WO2004072613

Publication Date: 2004-08-26

Authors: John T. McDevitt, Adrian Goodey, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

The development of miniaturized chromatographic systems localized within individual polymer microspheres and their incorporation into a bead-based cross-reactive sensor array platform is described herein. The integrated chromatographic and detection concept is based on the creation of distinct functional layers within the microspheres. In this first example of the new methodology, complexing ligands have been selectively immobilized to create "separation" layers harboring an affinity for various analytes. Information concerning the identities and concentrations of analytes may be drawn from the temporal properties of the beads' optical responses. Varying the nature of the ligand in the separation shell yields a collection of cross-reactive sensing elements well suited for use in array-based micro-total-analysis systems.

80. Multi-shell microspheres with integrated chromatographic and detection layers for use in array sensors

CA Publication No. CA2515305

Publication Date: 2004-08-26

Authors: John T. McDevitt, Adrian Goodey, Jason B. Shear, Dean P. Neikirk & Eric V. Anslyn

81. Method and apparatus for the delivery of samples to a chemical sensor array

AU Publication No. AU773679

Publication Date: 2004-06-03

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

82. Method and apparatus for the delivery of samples to a chemical sensor array

US Publication No. US6713298

Publication Date: 2004-03-30

Authors: Eric V. Anslyn, Jason B. Shear, John T. McDevitt & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

83. System and method for the analysis of bodily fluids

US Publication No. US2004053322

Publication Date: 2004-03-18

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

84. Sensor arrays for the measurement and identification of multiple analytes in solutions

AU Publication No. AU770949

Publication Date: 2004-03-11

Authors: Eric V. Anslyn, Jason B. Shear, John T. McDevitt & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavitites may be formed. A series of chemically sensitive particles microspheres are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

85. Method and system for the detection of cardiac risk factors

US Publication No. US2004029259

Publication Date: 2004-02-12

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Nick J. Christodoulides

A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

86. Capture and detection of microbes by membrane methods

AU Publication No. AU2003256742

Publication Date: 2004-02-09

Authors: Adrian Goodey, Dean Neikirk, Eric Anslyn, Jason Shear, John T. McDevitt, Pierre Floriano & Nick J. Christodoulides

87. Capture and detection of microbes by membrane methods

WO Publication No. WO2004009840

Publication Date: 2004-01-29

Authors: John T. McDevitt, Pierre Floriano, Nick J. Christodoulides, Adrian Goodey, Dean Neikirk, Eric Anslyn & Jason Shear

Methods and systems for detecting the presence of analytes using a membrane based detection system are described. A fluid sample is passed through a membrane based detection system (100). Particulate analytes (e.g., microbes) are captured by the membrane (110). Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.

88. Capture and detection of microbes by membrane methods

CA Publication No. CA2494727

Publication Date: 2004-01-29

Authors: Dean Neikirk, Eric Anslyn, Jason Shear, Adrian Goodey, Nick J. Christodoulides, Pierre Floriano & John T. McDevitt

89. Sensor arrays for the measurement and identification of multiple analytes in solutions

US Publication No. US6680206

Publication Date: 2004-01-20

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

90. Method and apparatus for the confinement of materials in a micromachined chemical sensor array

EP Publication No. EP1373874

Publication Date: 2004-01-02

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Byunghwa Park & Yoon Sok Park

91. Method of preparing a sensor array

US Publication No. US6649403

Publication Date: 2003-11-18

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

92. Method and system for the detection of cardiac risk

WO Publication No. WO03090605

Publication Date: 2003-11-06

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, & Nick J. Christodoulides

A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle.; Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

93. Method and system for the detection of cardiac risk

CA Publication No. CA2523626

Publication Date: 2003-11-06

Authors: Dean P. Neikirk, John T. McDevitt, Nick J. Christodoulides, Eric V. Anslyn & Jason B. Shear

94. Detection system based on an analyte reactive particle

US Publication No. US6602702

Publication Date: 2003-08-05

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

95. General signaling protocols for chemical receptors in immobilized matrices

AU Publication No. AU1429701

Publication Date: 2003-07-08

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

96. Method and system for collecting and transmitting chemical information

US Publication No. US2003064422

Publication Date: 2003-04-03

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

97. Magnetic-based placement and retention of sensor elements in a sensor array

AU Publication No. AU2002330841

Publication Date: 2003-01-02

Authors: Eric V. Anslyn, Jason B. Shear, John T. McDevitt & Dean P. Neikirk

98. Magnetic-based placement and retention of sensor elements in a sensor array

WO Publication No. WO02103371

Publication Date: 2002-12-27

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

99. Method and apparatus for the confinement of materials in a micromachined chemical sensor array

US Publication No. US02061392

Publication Date: 2002-12-27

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Byunghwa

100. Method and apparatus for the confinement of materials in a micromachined chemical sensor array

US Publication No. US2002197622

Publication Date: 2002-12-26

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Byunghwa Park & Yoon Sok Park

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

101. Magnetic-based placement and retention of sensor elements in a sensor array

US Publication No. US2002160363

Publication Date: 2002-10-31

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

102. Method and apparatus for the confinement of materials in a micromachined chemical sensor array

CA Publication No. CA2437558

Publication Date: 2002-08-08

Authors: Jason B. Shear, Dean P. Neikirk, Byunghwa Park, Eric V. Anslyn, Yoon Sok Park & John T. McDevitt

103. Method and system for collecting and transmitting chemical information

AU Publication No. AU4719501

Publication Date: 2001-08-07

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

104. Method of preparing a sensor array

AU Publication No. AU3470901

Publication Date: 2001-08-07

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

105. Portable sensor array system

AU Publication No. AU3320001

Publication Date: 2001-08-07

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

106. System and Method for analysis of bodily fluids

AU Publication No. AU3659701

Publication Date: 2001-08-07

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

107. System for transferring fluid samples through a sensor array

AU Publication No. AU3801101

Publication Date: 2001-08-07

Authors: John T. McDevitt, Eric v. Anslyn, Jason B. Shear, Dean P. Neikirk & Young-Soo Sohn

108. Method of preparing a sensor array

WO Publication No. WO0155703

Publication Date: 2001-08-02

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

109. Portable sensor array system

WO Publication No. WO0155702

Publication Date: 2001-08-02

Authors: ohn T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

110. Portable sensor array system

CA Publication No. CA2401782

Publication Date: 2001-08-02

Authors: Dean P. Neikirk, Jason B. Shear, Eric V. Ansyln & John T. McDevitt

111. System and Method for analysis of bodily fluids

WO Publication No. WO0155701

Publication Date: 2001-08-02

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a ligth source, a sensor array , and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using patten recognition techniques, the analytes within a multi-analyte fluid may be characterized.

112. System for transferring fluid samples through a sensor array

WO Publication No. WO0155704

Publication Date: 2001-08-02

Authors: John T. McDevitt, Eric v. Anslyn, Jason B. Shear, Dean P. Neikirk & Young-Soo Sohn

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

113. Sensor arrays for the measurement and identification of multiple analytes in solutions

EP Publication No. EP1097369

Publication Date: 2001-05-09

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

114. Jc in high magnetic field of bi-layer and multi-layer structures for high temperature superconductive materials

US Publication No. US6221812

Publication Date: 2001-04-24

Authors: Jiping Zhou, John T. McDevitt & John B. Goodenough

To improve the chemical stability, as well as the critical current density (JC) of a superconductive material in an external magnetic field, copper-oxide coating materials have been developed. In some embodiments, these coating materials include a composition with the formula R1-xCaxBa2-yLayCu3-zMzO7-delta, where R is a rare-earth element (e.g., La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, or Y), M is a transition metal (e.g., Mn, Re, Fe, Os, Co, Rh, Ir, Ni, Pd, Pt, Ag, Au, Zn, Cd, or Hg), 0<=x<=0.4, 0<=y<=0.4, and 0<=z<=1.0. These coating materials are preferably used as a surface layer on superconductive materials to impart corrosion resistance and an improved critical current density when the layers are exposed to magnetic fields

115. Detection system based on an analyte reactive particle

AU Publication No. AU1325201

Publication Date: 2001-02-05

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

116. General signaling protocols for chemical receptors in immobilized matrices

US Publication No. US6589779

Publication Date: 2001-02-05

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

117. Detection system based on an analyte reactive particle

WO Publication No. WO0106253

Publication Date: 2001-01-25

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

118. General signaling protocols for chemical receptors in immobilized matrices

WO Publication No. WO0106244

Publication Date: 2001-01-25

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

119. Method and apparatus for the delivery of samples to a chemical sensor array

WO Publication No. WO0106239

Publication Date: 2001-01-25

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk & Damon V. Borich

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

120. Method and apparatus for the delivery of samples to a chemical sensor array

CA Publication No. CA2379130

Publication Date: 2001-01-25

Authors: Damon V. Borich, John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

121. Method and system for remotely collecting and evaluating chemical/biochemical information

AU Publication No. AU4990500

Publication Date: 2000-11-21

Authors: Eric V. Anslyn, Sherry L. Acanfora-Florin, Damon Borich, James W. Douglas, John T. McDevitt, John A. McMorris III, Gregory A. Mullins, Dean B. Neikirk, Mike J. Otworth, John S. Scott & Jason B. Shear

122. Method and system for remotely collecting and evaluating chemical/biochemical information

WO Publication No. WO0068670

Publication Date: 2000-11-16

Authors: Eric V. Anslyn, Sherry L. Acanfora-Florin, Damon Borich, James W. Douglas, John T. McDevitt, John A. McMorris III, Gregory A. Mullins, Dean B. Neikirk, Mike J. Otworth, John S. Scott & Jason B. Shear

The present invention provides a method and system for detecting analytes in a fluid sample in a system of interest. The method and system includes a sensor, which includes at least one reactant, having an integral detector. The detector detects spectroscopic changes of reactants as the fluid sample passes over the reactants. The spectroscopic changes are caused by an analyte present in the fluid sample interacting with reactants.

123. Sensor arrays for the measurement and identification of multiple analytes in solutions

AU Publication No. AU5316599

Publication Date: 2000-02-07

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

124. Method and system for collecting and transmitting chemical information

WO Publication No. WO0155952

Publication Date: 2000-01-31

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

125. Sensor arrays for the measurement and identification of multiple analytes in solutions

WO Publication No. WO0004372

Publication Date: 2000-01-27

Authors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear & Dean P. Neikirk

126. Sensor arrays for the measurement and identification of multiple analytes in solutions

CA Publication No. CA2337155

Publication Date: 2000-01-27

Authors: John T. McDevitt, Dean P. Neikirk, Eric V. Anslyn & Jason B. Shear

127. Molecular level, precision control over the interfacial properties of high-TC superconductor structures and devices

US Publication No. US5846909

Publication Date: 1998-12-08

Authors: John T. McDevitt & Chad A. Mirkin

Use of monolayer films for the direct modification of high-Tc superconductor structures and devices. Methods for the formation of superconductor localized monolayer films have been discovered based on the spontaneous adsorption of molecules containing ligating functionalities, such as alkylamine, arylamine, and alkylthiol moieties. Molecules containing these types of functionalities are found to bind tenaciously to the metal ions which form the high-Tc superconductor surface. The derivatized superconductor structures can be prepared simply by soaking the high-Tc, superconductor structure or device in a dry organic solvent system which contains the derivatizing agent. Large changes in the superconductor interfacial properties can be achieved with such procedures allowing for the atomic level control of the surface properties of the superconductor. This discovery is particularly important to provide a) new methods to fabricate superconductor devices with atomic level precision, b) to form defect-free anti-corrosion layers, c) improved/optimized methods for lithographic processing of high-Tc devices, and d) improved adhesion of protective layers by surface-modification.

128. Hybrid, dye antenna/thin film superconductor devices and methods of tuned photo-responsive control thereof

US Publication No. US5600172

Publication Date: 1997-02-04

Authors: John T. McDevitt & David C. Jurbergs

A surface of a thin film superconductor element is coated with a layer containing pre-selected dye, or multiple dyes, alone or in combination with intermediate reflective coatings (best mode), which, when maintained near Tc, upon exposure to a selected frequency of light acts as a narrow bandwidth absorber to change the resistive property of the underlying superconductor following energy transfer from the dye to the superconductor. The resistance change is electronically detectable to function as a wavelength selective high speed optoelectronic switch or sensor element. A plurality of elements can be arrayed with each element junction being sensitized by overcoating with a different dye layer, either alone or in combination with an underlying reflective coating, so that upon exposure to a broad spectrum or polychromic light source, the individual junctions will independently be switched or not depending on the wavelength to which the superconductor junction is tuned by the pre-selected dye, thereby permitting multiplexed photo-optical message transmission and detection. For example, a single optical fiber may carry several signals simultaneously, each of which is encoded in a different color ( lambda ) and transmitted as a polychromic beam. The array distinguishes between signals as each detector is tuned to a selected encoded light color.

129. Chemically tailored corrosion resistant high-TC superconductors

US Publication No. US5591696

Publication Date: 1997-01-07

Authors: John. T. McDevitt, JI-Ping Zhuo, & Jianai Zhao

A corrosion resistant high temperature superconductor and a method of preparing said superconductors involving substitution of ions in the lattice to relieve stress and strain caused by mismatched bond lengths. Specific examples of such superconductors are Y1-yCayBa2-yLayCu3O7-d where O<y<1.0 and O<d<1 and YBa2-ySryCu3O7-d where 0<y<2 and O<d<1. In YBa2Cu3O7-d structure, the internal stresses estimated from the difference between the bond valence sum and the formal oxidation state for Ba and Cu ions indicate that the Ba atom is too large for Cu-O cage at oxygen stoichiometric d=0 and too small at d=1. Therefore, the Ba (1.52 ANGSTROM ) is substituted by La (1.27 ANGSTROM ) and for keeping the same oxidation state of Cu as in the prototype material the Ca (1.12 ANGSTROM ) equivalent to La replaces the Y (1.019 ANGSTROM )

130. Chemically tailored corrosion resistant high-TC superconductor thin film structures and devices

AU Publication No. AU4130696

Publication Date: 1996-05-02

Authors: John. T. McDevitt, JI-Ping Zhuo, & Jianai Zhao

131. Chemically tailored corrosion resistant high-TC superconductor thin film structures and devices

WO Publication No. WO9611482

Publication Date: 1996-04-18

Authors: John. T. McDevitt, JI-Ping Zhuo, & Jianai Zhao

A corrosion resistant high temperature superconductor and a method of preparing said superconductors involving substitution of ions in the lattice to relieve stress and strain caused by mismatches bond lengths. Specific examples of such superconductors are Y1-yCayBa2-yLayCu3O7-d where O < y < 1.0 and O < d < 1 and YBa2-ySryCu3O7-d where O < y < 2 and O < d < 1. In YBa2Cu3O7-d structure, the internal stresses estimated from the difference between the bond valence sum and the formal oxidation state for Ba and Cu ions indicate that the Ba atom is too large for Cu-O cage at oxygen stoichiometric d = 0 and too small at d = 1. Therefore, the Ba (1.52 ANGSTROM ) is substituted by La (1.27 ANGSTROM ) and for keeping the same oxidation state of Cu as in the prototype material the Ca (1.12 ANGSTROM ) equivalent to La replaces the Y (1.019 ANGSTROM ). Various geometries for the stable superconductor formulations are described including monolithic bulk ceramic, encapsulated ceramic, monolithic film, encapsulated film and superlattice forms.